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AXSMAxsome Therapeutics, Inc. · Insider ownership research

Axsome Therapeutics, Inc. insiders sold $134M in the past 12 months. How much of their stake is that?

Insiders sold $134M in the past 12 months.100% was sold under disclosed trading plans. The largest seller, Herriot Tabuteau (Chief Executive Officer, Director), sold $97.8M. 97% of these sales were shares from exercising options.Share-of-stake figures for this company are being verified and will be added when that check is finished. Why

Updated Oct 13, 2026 from SEC filings · covers Oct 14, 2025 to Oct 13, 2026
$97.8M
largest seller, Herriot Tabuteau, past 12 months
100%
of sales were under disclosed trading plans, past 12 months
8 of 9
officers and directors sold shares, past 12 months
Is this normal? More than usual: about 7x the 5-year average. 8 insiders sold; the average is 2 a year. Year by year
Latest filing: Filed Sep 3 for a sale on Sep 3. Mark Jacobson sold 10K shares ($2.1M) under a disclosed plan. Filing
SEC ownership filings: 39 filed in the 12 months to Oct 13, 2026; 211 on record since Nov 19, 2015 · See the evidence

What stands out

Routine activity: 100% of sales were under disclosed plans, and no insider sold more than 1% of vested holdings.

A share of stake is shown for 0 of the 8 officers and directors who sold. 9 are left out

i
Left out: Herriot Tabuteau, Mark Coleman, Roger Jeffs, Nick Pizzie, Mark Saad, Mark Jacobson, Hunter Murdock, Susan Mahony and Ari Maizel (share of stake is being verified).
Disclosed company stock is not an insider's whole wealth.

Who sold, and how much of their stake

Officers and directors, past 12 months. Their share of stake is being verified and is not shown yet; amounts and trading plans are below.

Herriot Tabuteau
Chief Executive Officer, Director
Not confirmed
Share of stake not shown: share of stake is being verified. Why
$97.8MDisclosed plan
Nick Pizzie
Chief Financial Officer
Not confirmed
Share of stake not shown: share of stake is being verified. Why
$10.2MDisclosed plan
Mark Jacobson
Chief Operating Officer
Not confirmed
Share of stake not shown: share of stake is being verified. Why
$8.9MDisclosed plan
Mark Coleman
Director
Not confirmed
Share of stake not shown: share of stake is being verified. Why
$8.2MDisclosed plan
Mark Saad
Director
Not confirmed
Share of stake not shown: share of stake is being verified. Why
$6.2MDisclosed plan
All 8 sellers

Selling by month

Officers and directors, Oct 2025 to Oct 2026. Each sale is counted once: under a disclosed plan, else to cover taxes, else no plan disclosed.

Disclosed planOne dollar scale for every month; the tallest bar is labeled
OctNov 2025: $21.8M under a disclosed planNovDec 2025: $17.9M under a disclosed planDecJan 2026: $27.5M under a disclosed plan$27.5MJanFeb 2026: $15.8M under a disclosed planFebMarApr 2026: $1.4M under a disclosed planAprMay 2026: $2.5M under a disclosed planMayJun 2026: $23.0M under a disclosed planJunJul 2026: $11.9M under a disclosed planJulAug 2026: $10.5M under a disclosed planAugSep 2026: $2.1M under a disclosed planSepOct

Recent activity

Past 30 days, Sep 14, 2026 to Oct 13, 2026

No officer or director trades were reported for the past 30 days. The most recent before that:

Sep 3, 2026Mark Jacobson sold 10K shares ($2.1M) under a disclosed trading plan. 10K shares came in from vesting or option exercises the same day, so the holding rose by 0 net.
WhoSharesPrice% of total stakeTotal stake afterTrade dateFiled
Mark Jacobson
Chief Operating Officer
10,000$208.65n/an/aSep 3, 2026Sep 3, 2026

Common questions

Is the Axsome Therapeutics, Inc. CEO selling stock?

Yes. Herriot Tabuteau sold 565K shares ($97.8M) in the past 12 months, all of it under a trading plan disclosed in the filings.

Why are Axsome Therapeutics, Inc. insiders selling?

Filings rarely give a reason, and we don't guess at one. What they show is how the sales were made: 100% of sales by value ran under 10b5-1 trading plans disclosed in the filings. A trading plan schedules sales in advance.

Are any Axsome Therapeutics, Inc. insiders buying?

No. Officers and directors reported no purchases in the past 12 months.

The evidence

Who sold8 officers and directors: amount, % of holdings, trading plan
Who soldAmount% of holdingsTrading plan
Herriot Tabuteau
Chief Executive Officer, Director
$97.8M
565K shares
Not confirmed
share of stake is being verified. Why
Disclosed plan
Nick Pizzie
Chief Financial Officer
$10.2M
45K shares
Not confirmed
share of stake is being verified. Why
Disclosed plan
Mark Jacobson
Chief Operating Officer
$8.9M
50K shares
Not confirmed
share of stake is being verified. Why
Disclosed plan
Mark Coleman
Director
$8.2M
43K shares
Not confirmed
share of stake is being verified. Why
Disclosed plan
Mark Saad
Director
$6.2M
38K shares
Not confirmed
share of stake is being verified. Why
Disclosed plan
Ari Maizel
Chief Commercial Officer
$2.8M
15K shares
Not confirmed
share of stake is being verified. Why
Disclosed plan
Susan Mahony
Director
$145K
600 shares
Not confirmed
share of stake is being verified. Why
Disclosed plan
Roger Jeffs
Director
$142K
572 shares
Not confirmed
share of stake is being verified. Why
Disclosed plan
The full ownership picture0 of 9 officers and directors confirmed

Vested shares across all share classes, held directly and through trusts, LLCs and family members, as reported on SEC Forms 3, 4 and 5. Unvested awards and options are never counted as owned shares.

InsiderHeld Oct 13, 2025SoldHeld Oct 13, 2026Still held
Herriot Tabuteau
!
Holdings and share of stake are being verified. Share-of-stake figures and holdings for this company are held back while they are verified. Sales and other transactions for Herriot Tabuteau are complete.
Chief Executive Officer, Director
n/a−565Kn/an/a
Vesting, gifts, unvested awards and holding lines for Herriot Tabuteau

Holdings and share of stake are being verified. Sales, proceeds, plan and tax status and dates for Herriot Tabuteau are complete; balances and unit counts will be added when the check is finished.

0gifted (net of own trusts)

Stock options (not counted as shares):

Options heldStrike priceExpiresIntrinsic value (estimate)
87,192$84.00Feb 26, 2034$10.9M
28,887$137.75Feb 20, 2035$2.0M
496,093$118.96May 27, 2026$44.5M
480,839$117.37May 27, 2026$43.9M
461,120$114.19May 27, 2026$43.6M
441,900$120.17May 27, 2026$39.1M
428,510$118.77May 27, 2026$38.5M
415,736$118.84May 27, 2026$37.3M
324,031$132.34May 27, 2026$24.7M
273,572$133.79May 27, 2026$20.5M
251,797$134.49May 27, 2026$18.7M
202,545$144.59May 27, 2026$13.0M
182,382$146.94May 27, 2026$11.3M
171,824$148.18May 27, 2026$10.4M
93,121$171.28May 27, 2026$3.5M
63,671$172.33May 27, 2026$2.3M
32,410$170.38May 27, 2026$1.2M
99,330$241.01Mar 15, 2027$0
49,664$240.25Mar 15, 2027$0
4,660$212.01Mar 15, 2027$0

Estimate: options held × ($208.65 − strike price), using the most recent insider trade price on Form 4 (Sep 3, 2026), not a market close.

Mark Coleman
!
Holdings and share of stake are being verified. Share-of-stake figures and holdings for this company are held back while they are verified. Sales and other transactions for Mark Coleman are complete.
Director
n/a−43Kn/an/a
Vesting, gifts, unvested awards and holding lines for Mark Coleman

Holdings and share of stake are being verified. Sales, proceeds, plan and tax status and dates for Mark Coleman are complete; balances and unit counts will be added when the check is finished.

0gifted (net of own trusts)

Stock options (not counted as shares):

Options heldStrike priceExpiresIntrinsic value (estimate)
7,721$4.95Mar 14, 2027$1.6M
5,799$73.90Jun 7, 2034$781K
3,166$111.91Jun 6, 2035$306K

Estimate: options held × ($208.65 − strike price), using the most recent insider trade price on Form 4 (Sep 3, 2026), not a market close.

Roger Jeffs
!
Holdings and share of stake are being verified. Share-of-stake figures and holdings for this company are held back while they are verified. Sales and other transactions for Roger Jeffs are complete.
Director
n/a−572n/an/a
Vesting, gifts, unvested awards and holding lines for Roger Jeffs

Holdings and share of stake are being verified. Sales, proceeds, plan and tax status and dates for Roger Jeffs are complete; balances and unit counts will be added when the check is finished.

0gifted (net of own trusts)

Stock options (not counted as shares):

Options heldStrike priceExpiresIntrinsic value (estimate)
1,425$84.00Feb 26, 2034$178K
5,799$73.90Jun 7, 2034$781K
1,408$137.75Feb 20, 2035$100K
3,166$111.91Jun 6, 2035$306K

Estimate: options held × ($208.65 − strike price), using the most recent insider trade price on Form 4 (Sep 3, 2026), not a market close.

Nick Pizzie
!
Holdings and share of stake are being verified. Share-of-stake figures and holdings for this company are held back while they are verified. Sales and other transactions for Nick Pizzie are complete.
Chief Financial Officer
n/a−45Kn/an/a
Vesting, gifts, unvested awards and holding lines for Nick Pizzie

Holdings and share of stake are being verified. Sales, proceeds, plan and tax status and dates for Nick Pizzie are complete; balances and unit counts will be added when the check is finished.

0gifted (net of own trusts)

Stock options (not counted as shares):

Options heldStrike priceExpiresIntrinsic value (estimate)
28,722$84.00Feb 26, 2034$3.6M
9,516$137.75Feb 20, 2035$675K
72,000$3.50May 16, 2028$14.8M

Estimate: options held × ($208.65 − strike price), using the most recent insider trade price on Form 4 (Sep 3, 2026), not a market close.

Mark Saad
!
Holdings and share of stake are being verified. Share-of-stake figures and holdings for this company are held back while they are verified. Sales and other transactions for Mark Saad are complete.
Director
n/a−38Kn/an/a
Vesting, gifts, unvested awards and holding lines for Mark Saad

Holdings and share of stake are being verified. Sales, proceeds, plan and tax status and dates for Mark Saad are complete; balances and unit counts will be added when the check is finished.

0gifted (net of own trusts)

Stock options (not counted as shares):

Options heldStrike priceExpiresIntrinsic value (estimate)
1,519$84.00Feb 26, 2034$189K
5,799$73.90Jun 7, 2034$781K
1,494$137.75Feb 20, 2035$106K
3,166$111.91Jun 6, 2035$306K

Estimate: options held × ($208.65 − strike price), using the most recent insider trade price on Form 4 (Sep 3, 2026), not a market close.

Mark Jacobson
!
Holdings and share of stake are being verified. Share-of-stake figures and holdings for this company are held back while they are verified. Sales and other transactions for Mark Jacobson are complete.
Chief Operating Officer
n/a−50Kn/an/a
Vesting, gifts, unvested awards and holding lines for Mark Jacobson

Holdings and share of stake are being verified. Sales, proceeds, plan and tax status and dates for Mark Jacobson are complete; balances and unit counts will be added when the check is finished.

0gifted (net of own trusts)

Stock options (not counted as shares):

Options heldStrike priceExpiresIntrinsic value (estimate)
104,954$12.95Mar 19, 2029$20.5M
32,825$84.00Feb 26, 2034$4.1M
10,875$137.75Feb 20, 2035$771K

Estimate: options held × ($208.65 − strike price), using the most recent insider trade price on Form 4 (Sep 3, 2026), not a market close.

Hunter Murdock
!
Holdings and share of stake are being verified. Share-of-stake figures and holdings for this company are held back while they are verified. Sales and other transactions for Hunter Murdock are complete.
General Counsel
n/a0n/an/a
Vesting, gifts, unvested awards and holding lines for Hunter Murdock

Holdings and share of stake are being verified. Sales, proceeds, plan and tax status and dates for Hunter Murdock are complete; balances and unit counts will be added when the check is finished.

0gifted (net of own trusts)

Stock options (not counted as shares):

Options heldStrike priceExpiresIntrinsic value (estimate)
16,369$29.91Mar 4, 2032$2.9M
23,593$84.00Feb 26, 2034$2.9M
7,816$137.75Feb 20, 2035$554K

Estimate: options held × ($208.65 − strike price), using the most recent insider trade price on Form 4 (Sep 3, 2026), not a market close.

Susan Mahony
!
Holdings and share of stake are being verified. Share-of-stake figures and holdings for this company are held back while they are verified. Sales and other transactions for Susan Mahony are complete.
Director
n/a−600n/an/a
Vesting, gifts, unvested awards and holding lines for Susan Mahony

Holdings and share of stake are being verified. Sales, proceeds, plan and tax status and dates for Susan Mahony are complete; balances and unit counts will be added when the check is finished.

0gifted (net of own trusts)

Stock options (not counted as shares):

Options heldStrike priceExpiresIntrinsic value (estimate)
191$84.00Feb 26, 2034$24K
5,799$73.90Jun 7, 2034$781K
1,312$137.75Feb 20, 2035$93K
3,166$111.91Jun 6, 2035$306K

Estimate: options held × ($208.65 − strike price), using the most recent insider trade price on Form 4 (Sep 3, 2026), not a market close.

Ari Maizel
!
Holdings and share of stake are being verified. Share-of-stake figures and holdings for this company are held back while they are verified. Sales and other transactions for Ari Maizel are complete.
Chief Commercial Officer
n/a−15Kn/an/a
Vesting, gifts, unvested awards and holding lines for Ari Maizel

Holdings and share of stake are being verified. Sales, proceeds, plan and tax status and dates for Ari Maizel are complete; balances and unit counts will be added when the check is finished.

0gifted (net of own trusts)

Stock options (not counted as shares):

Options heldStrike priceExpiresIntrinsic value (estimate)
23,710$70.73Sep 25, 2033$3.3M
23,593$84.00Feb 27, 2034$2.9M
7,816$137.75Feb 20, 2035$554K

Estimate: options held × ($208.65 − strike price), using the most recent insider trade price on Form 4 (Sep 3, 2026), not a market close.

Holdings and share of stake for Axsome Therapeutics, Inc. are being verified, so no balances, unit counts or percentages are shown. Sales, proceeds, plan and tax status, titles and dates come straight from individual filings.

What explains the selling$134M of sales by plan status, purpose, seller and month

Officer and director open-market sales: $134M across 756,793 shares. Plan status and stated purpose are separate questions, and a sale can have both.

By plan status

Taxes

$447K of sales (0.3%) cite tax obligations in their footnotes, $447K of them also under a plan. Example: Roger Jeffs, Jun 11, 2026

SellerShares soldProceedsUnder a disclosed planShare of totalSales dates
Herriot Tabuteau
Chief Executive Officer, Director
565K$97.8M100%73%Nov 3, 2025 to Aug 6, 2026
Nick Pizzie
Chief Financial Officer
45K$10.2M100%8%Jan 22, 2026 to Jun 9, 2026
Mark Jacobson
Chief Operating Officer
50K$8.9M100%7%Feb 26, 2026 to Sep 3, 2026
Mark Coleman
Director
43K$8.2M100%6%Feb 26, 2026 to Jun 10, 2026
Mark Saad
Director
38K$6.2M100%5%Dec 31, 2025 to Dec 31, 2025
Ari Maizel
Chief Commercial Officer
15K$2.8M100%2%Jan 21, 2026 to Apr 22, 2026
Susan Mahony
Director
600$145K100%0.1%Jun 9, 2026 to Jun 10, 2026
Roger Jeffs
Director
572$142K100%0.1%Jun 10, 2026 to Jun 11, 2026

Sales by month

MonthSale proceedsDisclosed planTo cover taxesNo plan disclosed
Oct 2025$0$0$0$0
Nov 2025$21.8M$21.8M$0$0
Dec 2025$17.9M$17.9M$0$0
Jan 2026$27.5M$27.5M$0$0
Feb 2026$15.8M$15.8M$0$0
Mar 2026$0$0$0$0
Apr 2026$1.4M$1.4M$0$0
May 2026$2.5M$2.5M$0$0
Jun 2026$23.0M$23.0M$0$0
Jul 2026$11.9M$11.9M$0$0
Aug 2026$10.5M$10.5M$0$0
Sep 2026$2.1M$2.1M$0$0
Oct 2026$0$0$0$0
Is this normal? Selling year by year5 earlier years to compare with

More than usual: about 7x the 5-year average. 8 insiders sold; the average is 2 a year.

12 months endingShares soldInsiders who soldProceeds
Oct 13, 2026
Latest 12 months
757K8$134M
Oct 13, 2025
1 year earlier
411K7$47.4M
Oct 13, 2024
2 years earlier
134K4$10.6M
Oct 14, 2023
3 years earlier
30K1$2.2M
Oct 14, 2022
4 years earlier
00$0
Oct 14, 2021
5 years earlier
00$0

Open-market sales (Form 4 code S) by people who were officers or directors, in split-adjusted shares. Earlier years include people who have since left. A sale that an outside holder also reports (a family trust, a fund) is counted with outside holders in every year. Shares, not dollars, are compared, so a change in the stock price doesn't look like a change in selling. Years the filings don't fully cover are shown but left out of the average.

Known gaps and uncertainty9 officers and directors not confirmed

Holdings and share of stake are being verified. Balances, unit counts and every share-of-stake figure for Axsome Therapeutics, Inc. are held back until that check is finished. Sales, proceeds, plan and tax status, titles and dates come straight from individual filings and are complete.

External context: we only cite outside events when a documented connection exists. None is shown for this period.

Sources and methodology211 filings on record, 39 filed in the 12-month period, and how we read them

All 211 Forms 3, 4 and 5 on record for Axsome Therapeutics, Inc. (SEC CIK 1579428), filed from Nov 19, 2015 to Sep 3, 2026; 39 of them were filed in the 12 months this page covers, retrieved from SEC EDGAR on Oct 13, 2026. Prices are the ones reported in each filing, often weighted averages.

Holdings. Each holding line (a share class plus an owner, such as a trust or LLC) carries its last reported balance forward. Entities first reported during the period start at zero, so transfers between an insider's own trusts don't count as selling. Lines not reported for three years or more are listed separately and left out of totals.

Sales. A sale counts as under a 10b5-1 plan if its footnote cites one or the filing's Rule 10b5-1 box is checked, and as tax-related if its footnote cites tax obligations or sell-to-cover. Shares withheld by the company for taxes are listed separately. Sales with neither attribute are labeled "no plan disclosed".

Full methodology

Former or inactive filers (5)No filing in 18 months; last reported balances, not in any total
NameLast filedLast reported balance
David MarekMar 19, 2020No balance on record
Myrtle PotterJun 10, 2019No balance on record
John GolubieskiAug 8, 2017No balance on record
Constance AmesMar 17, 20174,358 shares, last reported balance as of Nov 24, 2015
Randall KayeDec 24, 201511,044 shares, last reported balance as of Dec 23, 2015

Spotted something wrong on this page? Report an error. We check every report against the SEC filing and list what we fix in the corrections log.